{"schema":"hottub-news/story/v1","story":"st_csbdqnbyrsxazjakhtya","title":"A novel mRNA cancer vaccine helps reduce the chances of melanoma patients' tumors returning","title_en":null,"outlets":173,"brief":{"text":"A personalized mRNA cancer vaccine, developed by Moderna and MSD, has been shown to reduce the risk of melanoma recurrence or death by 42% when combined with pembrolizumab immunotherapy [2][3][5][9]. The vaccine uses each patient's own tumor to create a personalized therapeutic cancer vaccine [2][3][5]. This approach has demonstrated promising results in a late-stage clinical trial [2][3][5][9]. According to the trial results, the combination of the personalized vaccine and immunotherapy significantly lowered the risk of melanoma recurrence or death [2][3][5][9].","sources":["n_mvqmbp6e7rsdfwvpnvdq","n_uuxvr6dofrycilzh3ekq","n_lpwut4rjbn2tq5nnenha","n_bkom75n5tbrtqg3s2fua","n_iqgym2ywvu4in2ynqd4q","n_wijate6pqo6z27sl4wdq","n_mylpyihch5su3yq4fohq","n_ktypwzoxpw3wp5qbgssq","n_36oxrsuvg5yc6dtee47a","n_ljc2nwpmtyta4tey2ukq"],"updated":"2026-10-24T00:02:12Z"},"page":"https://hottub.news/stories/experimental-mrna-vaccine-cuts-risk-melanoma-returns-by-42-csbdqnbyrs","count":189,"items":[{"id":"n_gaj4exhbqq5omjgivj4a","seq":4142624,"kind":"article","title":"Una vacuna contra el melanoma redueix 42% el risc de recaiguda","title_en":"A vaccine against melanoma reduces the risk of relapse by 42%","url":"https://www.elperiodico.cat/societat/20261024/vacuna-melanoma-redueix-42-risc-135703393","published":"2026-10-24T00:24:00Z","seen":"2026-10-24T02:55:00Z","lang":"ca","country":"ES","source":{"id":"elperiodico.cat","name":"elperiodico.cat","domain":"elperiodico.cat","outlet":{"wikidata":"Q35638","name":"El Periódico","type":"newspaper","country":"ES","designations":["newspaper"]}},"via":"gdelt-gkg-translingual","topics":["economy","health"],"authors":["El Peri&#xF3","dico"],"story":"st_csbdqnbyrsxazjakhtya","category":"health","category_p":0.9300000071525574,"sentiment":"positive","tone":-0.0,"political":0.05000000074505806},{"id":"n_hf7nixymjfccaodvupsa","seq":4121791,"kind":"article","title":"Nova vacina promete reduzir morte por melanoma (câncer de pele)","title_en":"New vaccine promises to reduce melanoma deaths","url":"https://www.otempo.com.br/saude-e-bem-estar/2026/10/23/nova-vacina-promete-reduzir-morte-por-melanoma-tipo-mais-agressivo-de-cancer-de-pele","published":"2026-10-24T00:00:00Z","seen":"2026-10-24T00:09:00Z","lang":"pt","country":"BR","source":{"id":"otempo.com.br","name":"otempo.com.br","domain":"otempo.com.br"},"via":"gdelt-gkg-translingual","topics":["economy","health","science","security"],"entities":[{"id":"Q180614","name":"melanoma","type":"other"}],"story":"st_csbdqnbyrsxazjakhtya","category":"health","category_p":0.8299999833106995,"sentiment":"positive","tone":-0.25,"political":0.10999999940395355},{"id":"n_mvqmbp6e7rsdfwvpnvdq","seq":4110741,"kind":"article","title":"Como funciona a vacina contra o câncer que reduz risco de morte por melanoma","title_en":"How the cancer vaccine that reduces the risk of death from melanoma works","url":"http://tribunaonline.com.br/saude/como-funciona-a-vacina-contra-o-cancer-que-reduz-risco-de-morte-por-melanoma-333425","published":"2026-10-23T23:00:00Z","seen":"2026-10-23T23:08:29Z","lang":"pt","country":"BR","source":{"id":"tribunaonline.com.br","name":"tribunaonline.com.br","domain":"tribunaonline.com.br","outlet":{"wikidata":"Q10358286","name":"Rede Tribuna","type":"other","country":"BR","designations":["enterprise"]}},"via":"gdelt-gkg-translingual","topics":["economy","security","science","health"],"authors":["Laiz Menezes","da Ag&#234","ncia Folhapress"],"story":"st_csbdqnbyrsxazjakhtya","category":"health","category_p":0.8999999761581421,"sentiment":"positive","tone":-0.3199999928474426,"political":0.10000000149011612},{"id":"n_uuxvr6dofrycilzh3ekq","seq":4111732,"kind":"article","title":"Experimental mRNA vaccine cuts risk that melanoma returns by 42%","url":"https://wsvn.com/news/us-world/moderna-merck-cancer-trial-success","summary":"(CNN) — When the news arrived in August that what could be the first personalized mRNA cancer vaccine had succeeded in a late-stage clinical trial...","published":"2026-10-23T22:45:01Z","seen":"2026-10-23T23:19:00Z","lang":"en","country":"US","source":{"id":"kite-wsvn-com-bfe84d","name":"wsvn.com","domain":"wsvn.com","outlet":{"wikidata":"Q7956000","name":"WSVN","type":"broadcaster","country":"US","designations":["television station"]}},"via":"kite-wsvn-com-bfe84d","topics":["florida","us & world","video"],"authors":["Matthew Garcia"],"image":"https://wsvn.com/wp-content/uploads/sites/2/2026/10/102326-doctors-office.png","story":"st_csbdqnbyrsxazjakhtya","category":"health","category_p":0.8199999928474426,"sentiment":"positive","tone":0.46000000834465027,"political":0.10999999940395355},{"id":"n_lpwut4rjbn2tq5nnenha","seq":4097420,"kind":"article","title":"Melanoma vaccine reduces death or cancer recurrence by 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42%","url":"https://www.capital.ro/moderna-si-merck-anunta-rezultate-pentru-vaccinul-anticancer-riscul-de-deces-sau-recidiva-a-melanomului-a-scazut-cu-42.html","published":"2026-10-23T22:00:00Z","seen":"2026-10-23T22:48:49Z","lang":"ro","country":"RO","source":{"id":"capital.ro","name":"capital.ro","domain":"capital.ro","outlet":{"wikidata":"Q5035439","name":"Capital","type":"magazine","designations":["periodical"]}},"via":"gdelt-gkg-translingual","topics":["economy","health","education","politics"],"entities":[{"id":"Q17081612","name":"Moderna","type":"org"},{"id":"Q96472579","name":"Merck","type":"org"}],"story":"st_csbdqnbyrsxazjakhtya","category":"health","category_p":0.6600000262260437,"sentiment":"positive","tone":-0.10999999940395355,"political":0.05999999865889549},{"id":"n_iqgym2ywvu4in2ynqd4q","seq":4103853,"kind":"article","title":"Cáncer de piel: una vacuna de ARNm redujo 42% el riesgo de recurrencia o muerte por melanoma","title_en":"Skin cancer: an mRNA vaccine reduced the risk of recurrence or death from melanoma by 42%","url":"https://eldebate.com.ar/cancer-de-piel-una-vacuna-de-arnm-redujo-42-el-riesgo-de-recurrencia-o-muerte-por-melanoma","published":"2026-10-23T22:00:00Z","seen":"2026-10-23T22:48:49Z","lang":"es","country":"AR","source":{"id":"eldebate.com.ar","name":"eldebate.com.ar","domain":"eldebate.com.ar","outlet":{"wikidata":"Q113995871","name":"El Debate","type":"newspaper","country":"AR","designations":["newspaper"]}},"via":"gdelt-gkg-translingual","topics":["economy","health","education","science"],"authors":["Redactor EL DEBATE"],"story":"st_csbdqnbyrsxazjakhtya","category":"health","category_p":0.8600000143051147,"sentiment":"positive","tone":-0.10999999940395355,"political":0.05000000074505806},{"id":"n_wijate6pqo6z27sl4wdq","seq":4100211,"kind":"article","title":"Como funciona a vacina contra o câncer que reduz risco de recidiva ou morte por melanoma","url":"https://jornaldebrasilia.com.br/noticias/saude/como-funciona-a-vacina-contra-o-cancer-que-reduz-risco-de-recidiva-ou-morte-por-melanoma","summary":"LAIZ MENEZES FOLHAPRESS A vacina de mRNA desenvolvida pelas farmacêuticas Moderna e MSD contra o melanoma, o tipo mais agressivo de câncer de pele, utiliza a tecnologia de RNA mensageiro (mRNA) para ensinar o sistema imunológico a reconhecer e combater células cancerígenas. Quando combinada com imunoterapia, a vacina reduziu em 42% o risco de recidiva ou morte por melanoma, segundo dados divulgados pelas empresas nesta quinta-feira (22). O objetivo do tratamento experimental…","published":"2026-10-23T21:33:36Z","seen":"2026-10-23T22:39:00Z","lang":"pt","country":"BR","source":{"id":"kite-jornaldebrasilia-com-br-148dda","name":"jornaldebrasilia.com.br","domain":"jornaldebrasilia.com.br"},"via":"kite-jornaldebrasilia-com-br-148dda","topics":["saúde","câncer","imunoterapia","intismeran autogene","tumor","vacina"],"authors":["Redação Jornal de Brasília"],"story":"st_csbdqnbyrsxazjakhtya","category":"health","category_p":0.8999999761581421,"sentiment":"positive","tone":0.28999999165534973,"political":0.10000000149011612},{"id":"n_mylpyihch5su3yq4fohq","seq":4091699,"kind":"article","title":"Vaksina e personalizuar kundër kancerit, studimi raporton ulje me 42% të rrezikut të vdekjes","url":"https://tiranatoday.al/vaksina-e-personalizuar-kunder-kancerit-studimi-raporton-ulje-me-42-te-rrezikut-te-vdekjes","summary":"Një vaksinë e personalizuar kundër kancerit, e përdorur së bashku me imunoterapinë Keytruda, ka dhënë rezultate inkurajuese te pacientët me melanomë me rrezik të lartë. Sipas rezultateve të përshkruara në studim, kombinimi uli me 42 për qind rrezikun e rikthimit të sëmundjes ose të vdekjes, krahasuar me trajtimin vetëm me Keytruda. Prova klinike e fazës […]","published":"2026-10-23T21:15:46Z","seen":"2026-10-23T21:46:06Z","lang":"sq","country":"AL","source":{"id":"kite-tiranatoday-al-d04ca8","name":"tiranatoday.al","domain":"tiranatoday.al"},"via":"kite-tiranatoday-al-d04ca8","topics":["bota"],"authors":["mirseda"],"story":"st_csbdqnbyrsxazjakhtya","category":"health","category_p":0.800000011920929,"sentiment":"positive","tone":0.3400000035762787,"political":0.05000000074505806},{"id":"n_5svb35dcezmepb7mw7kq","seq":4093113,"kind":"article","title":"Como funciona a vacina contra o câncer que reduz risco de recidiva ou morte por melanoma","url":"https://redir.folha.com.br/redir/online/emcimadahora/rss091/*https://www1.folha.uol.com.br/equilibrioesaude/2026/10/como-funciona-a-vacina-contra-o-cancer-que-reduz-risco-de-recidiva-ou-morte-por-melanoma.shtml","summary":"A vacina de mRNA desenvolvida pelas farmacêuticas Moderna e MSD contra o melanoma, o tipo mais agressivo de câncer de pele, utiliza a tecnologia de RNA mensageiro (mRNA) para ensinar o sistema imunológico a reconhecer e combater células cancerígenas. Leia mais (10/23/2026 - 18h01)","published":"2026-10-23T21:01:00Z","seen":"2026-10-23T21:49:01Z","lang":"pt","country":"BR","source":{"id":"kite-folha-uol-com-br-a7488b","name":"folha.uol.com.br","domain":"feeds.folha.uol.com.br"},"via":"kite-folha-uol-com-br-a7488b","authors":["author"],"story":"st_csbdqnbyrsxazjakhtya","category":"health","category_p":0.8999999761581421,"sentiment":"positive","tone":0.28999999165534973,"political":0.10000000149011612},{"id":"n_ktypwzoxpw3wp5qbgssq","seq":4082182,"kind":"article","title":"Personalised skin cancer vaccine cuts recurrence, death risk by 42%","url":"https://www.channelafrica.co.za/channelafrica/news/personalised-skin-cancer-vaccine-cuts-recurrence-death-risk-by-42","published":"2026-10-23T21:00:00Z","seen":"2026-10-23T21:24:32Z","lang":"en","country":"ZA","source":{"id":"channelafrica.co.za","name":"channelafrica.co.za","domain":"channelafrica.co.za","outlet":{"wikidata":"Q950992","name":"Channel Africa","type":"broadcaster","country":"ZA","designations":["radio station"]}},"via":"gdelt-gkg-english","topics":["health","economy","science"],"story":"st_csbdqnbyrsxazjakhtya","category":"health","category_p":0.8100000023841858,"sentiment":"positive","tone":-0.10999999940395355,"political":0.09000000357627869},{"id":"n_36oxrsuvg5yc6dtee47a","seq":4082757,"kind":"article","title":"New personalized cancer vaccine cuts Melanoma recurrence risk by 42%, trial shows","url":"https://www.thenews.com.pk/latest/1421078-new-personalized-cancer-vaccine-cuts-melanoma-recurrence-risk-by-42-trial-shows","published":"2026-10-23T20:51:00Z","seen":"2026-10-23T21:26:53Z","lang":"en","country":"PK","source":{"id":"thenews.com.pk","name":"thenews.com.pk","domain":"thenews.com.pk","outlet":{"wikidata":"Q835669","name":"The News International","type":"newspaper","designations":["daily newspaper"]}},"via":"gdelt-gkg-english","topics":["economy","health","science"],"story":"st_csbdqnbyrsxazjakhtya","category":"health","category_p":0.7400000095367432,"sentiment":"positive","tone":-0.25,"political":0.05999999865889549},{"id":"n_spsea22gqi47cbsm4rma","seq":4071592,"kind":"article","title":"Vaksina e personalizuar kundër kancerit, studimi raporton ulje me 42% të rrezikut të vdekjes","url":"https://www.balkanweb.com/vaksina-e-personalizuar-kunder-kancerit-studimi-raporton-ulje-me-42-te-rrezikut-te-vdekjes","summary":"Një vaksinë e personalizuar kundër kancerit, e përdorur së bashku me imunoterapinë Keytruda, ka dhënë rezultate inkurajuese te pacientët me melanomë me rrezik të lartë. Sipas rezultateve të përshkruara në studim, kombinimi uli me 42 për qind rrezikun e rikthimit të sëmundjes ose të vdekjes, krahasuar me trajtimin vetëm me Keytruda. Prova klinike e fazës […]","published":"2026-10-23T20:18:57Z","seen":"2026-10-23T20:31:00Z","lang":"sq","country":"AL","source":{"id":"kite-balkanweb-com-a9ef4a","name":"balkanweb.com","domain":"balkanweb.com","outlet":{"wikidata":"Q16837344","name":"Balkanweb","type":"website","designations":["website"]}},"via":"kite-balkanweb-com-a9ef4a","topics":["bota","lajmet e fundit","shëndeti","të gjitha"],"authors":["Sonila"],"story":"st_csbdqnbyrsxazjakhtya","category":"health","category_p":0.800000011920929,"sentiment":"positive","tone":0.3400000035762787,"political":0.05000000074505806},{"id":"n_ljc2nwpmtyta4tey2ukq","seq":4071503,"kind":"article","title":"Studimi i ri: Vaksina e personalizuar kundër kancerit ul me 42 për qind rrezikun e rikthimit të melanomës","url":"http://botasot.info/shendetesia/2542409/studimi-i-ri-vaksina-e-personalizuar-kunder-kancerit-ul-me-42-per-qind-rrezikun-e-rikthimit-te-melanomes","summary":"Një vaksinë e personalizuar kundër kancerit, e administruar së bashku me një ilaç imunoterapie, uli me 42 për qind rrezikun e vdekjes ose të rikthimit të melanomës, sipas rezultateve të një prove të madhe klinike ku morën pjesë......","published":"2026-10-23T20:06:03Z","seen":"2026-10-23T20:29:00Z","lang":"sq","country":"XK","source":{"id":"kite-botasot-info-ed234f","name":"botasot.info","domain":"botasot.info","outlet":{"wikidata":"Q894617","name":"Bota Sot","type":"newspaper","country":"CH","designations":["newspaper","periodical"]}},"via":"kite-botasot-info-ed234f","topics":["shëndetësia"],"image":"http://botasot.infohttps//cdn.botasot.info/botasot.info/images/2026/October/23/6adbb7982008a1792786046.webp?enlarge=1&width=851","mentions":2,"story":"st_csbdqnbyrsxazjakhtya","category":"health","category_p":0.8600000143051147,"sentiment":"positive","tone":0.36000001430511475,"political":0.029999999329447746},{"id":"n_u3ccju3z5qvrfsy4tvkq","seq":4055256,"kind":"article","title":"Breakthrough cancer vaccine reduces melanoma from returning by 42%, data shows","url":"https://abcnews.com/GMA/Wellness/breakthrough-cancer-vaccine-reduces-melanoma-returning-42-data/story?id=137509528","published":"2026-10-23T19:00:00Z","seen":"2026-10-23T19:02:08Z","lang":"en","source":{"id":"abcnews.com","name":"abcnews.com","domain":"abcnews.com"},"via":"gdelt-gkg-english","topics":["economy","health"],"authors":["ABC News"],"story":"st_csbdqnbyrsxazjakhtya","category":"health","category_p":0.7099999785423279,"sentiment":"positive","tone":-0.25,"political":0.07999999821186066},{"id":"n_jyduapqdgvb6qoqxz6ka","seq":4067279,"kind":"article","title":"Studimi i ri/ Vaksina e personalizuar kundër kancerit e ul me 42 për qind rrezikun e rikthimit të melanomës","url":"https://24-ore.com/studimi-i-ri-vaksina-e-personalizuar-kunder-kancerit-e-ul-me-42-per-qind-rrezikun-e-rikthimit-te-melanomes","published":"2026-10-23T18:49:00Z","seen":"2026-10-23T20:14:26Z","lang":"sq","source":{"id":"24-ore.com","name":"24-ore.com","domain":"24-ore.com"},"via":"gdelt-gkg-translingual","topics":["health","economy","education"],"story":"st_csbdqnbyrsxazjakhtya","category":"health","category_p":0.8500000238418579,"sentiment":"positive","tone":-0.3100000023841858,"political":0.029999999329447746},{"id":"n_nik5ynfepf7knpnpzzja","seq":4055942,"kind":"article","title":"Studimi i ri/ Vaksina e personalizuar kundër kancerit e ul me 42 për qind rrezikun e rikthimit të melanomës","url":"https://javanews.al/studimi-i-ri-vaksina-e-personalizuar-kunder-kancerit-e-ul-me-42-per-qind-rrezikun-e-rikthimit-te-melanomes","summary":"Një vaksinë e personalizuar kundër kancerit, e administruar së bashku me një ilaç imunoterapie, uli me 42 për qind rrezikun e vdekjes ose të rikthimit të melanomës, sipas rezultateve të një prove të madhe klinike ku morën pjesë më shumë se 1.000 pacientë. Prova klinike e fazës së tretë zbuloi se kombinimi i vaksinës me […]","published":"2026-10-23T18:43:37Z","seen":"2026-10-23T19:17:01Z","lang":"en","country":"AL","source":{"id":"kite-javanews-al-e71390","name":"javanews.al","domain":"javanews.al"},"via":"kite-javanews-al-e71390","topics":["bota","kryesoret","kuriozitete"],"authors":["A. 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Drugmakers Moderna, based in Cambridge, and Merck announced the results Thursday.","published":"2026-10-23T10:30:21Z","seen":"2026-10-23T11:25:00Z","lang":"en","country":"US","source":{"id":"kite-wbur-org-0f0dff","name":"wbur.org","domain":"rss.wbur.org"},"via":"kite-wbur-org-0f0dff","topics":["boston","news","health","science"],"authors":["WBUR"],"image":"https://media.wbur.org/wp/2026/10/Moderna_Cancer_Vaccine_26295714156396.jpg","mentions":3,"story":"st_csbdqnbyrsxazjakhtya","category":"health","category_p":0.8899999856948853,"sentiment":"positive","tone":0.5199999809265137,"political":0.07000000029802322},{"id":"n_55zvkodgeeaqizufmmmq","seq":3876082,"kind":"article","title":"La vacuna personalizada contra el cáncer reduce más de 40% el riesgo de muerte","url":"https://www.lavanguardia.com/vida/20261023/11666366/vacuna-personalizada-cancer-reduce-mas-40-riesgo-muerte.html","summary":"Moderna y Merck anuncian resultados positivos contra el melanoma en el ensayo de fase III, con más 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نتائج دراسة واسعة أنَّ لقاحاً شخصياً جديداً لعلاج السرطان طوّرته شركتا موديرنا وميرك، يُخفض خطر عودة سرطانالميلانوما بعد الجراحة بنسبة 42% خلال عامين، عند إضافته إلى العلاج المناعي المعتاد.ونُشرت النتائج التفصيلية الخميس، فيما كان مقرّراً عرضها السبت خلال اجتماع الجمعية الأوروبية لطبّ الأورام في مدريد.لقاح إنتيسميران الشخصي بتقنية mRNAيُعرف اللّقاح باسم إنتيسميران، ويعتمد على تقنية الحمض النووي الريبي المرسال (mRNA) المستخدمة في لقاحات كوفيد-19، لكنَّه يختلف عنها…","published":"2026-10-23T08:15:00Z","seen":"2026-10-23T08:37:00Z","lang":"ar","country":"LB","source":{"id":"kite-annahar-com-c768bb","name":"annahar.com","domain":"annahar.com","outlet":{"wikidata":"Q285097","name":"An-Nahar","type":"newspaper","country":"LB","designations":["daily newspaper"]}},"via":"kite-annahar-com-c768bb","topics":["middle-east","صحة 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