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据介绍，人体内大多数细胞都拥有相同的 DNA，但不同类型和状态的细胞会开启或关闭不同基因，以执行各自的生物学功能。例如，心肌细胞与正在应对感染的免疫细胞，其基因表达模式就存在明显差异。同一种 DNA 变异也可能在不同细胞中产生不同影响。 谷歌表示，此前发布的 AlphaGenome 主要预测 DNA 变异对不同组织整体分子活动的影响，难以充分识别特定细胞类型中的细微差异。AlphaGenome 2 则采用全新的条件模型架构，将目标组织、细胞类型或细胞状态作为输入，使模型能够针对特定生物学条件进行预测。 在训练数据方面，AlphaGenome 2 使用了来自人类和小鼠样本的超过 1.07 亿个单细胞图谱，覆盖 68…","published":"2026-11-11T23:28:24Z","seen":"2026-11-12T00:22:01Z","lang":"zh","country":"CN","source":{"id":"kite-ithome-com-f1cdd0","name":"ithome.com","domain":"ithome.com","outlet":{"wikidata":"Q28413779","name":"IThome","type":"website","country":"CN","designations":["website"]}},"via":"kite-ithome-com-f1cdd0","story":"st_kberqnck4z4u6dwhwvvq","category":"science-technology","category_p":0.9599999785423279,"sentiment":"neutral","tone":0.20999999344348907,"political":0.019999999552965164},{"id":"n_334nbe2gy6uxvi4eesda","seq":10031714,"kind":"article","title":"Alphabet's DeepMind unveils new AlphaGenome 2 model aimed at reading DNA cells 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变异对宽泛组织的分子活性影响，并推出了覆盖人类基因组全部 90 亿种单字母变异预测的 AlphaGenome Atlas ，助力罕见病、复杂性状与基础生物学研究。 AlphaGenome 2 从宽泛组织平均水平缩小至单个细胞类型与状态，并重构了模型架构，变异预测性能实现阶跃式提升，可捕捉宽泛组织模型中遗漏的疾病相关细胞中的变异效应，还能对模型未见过的细胞与疾病状态做出预测。 据IT之家了解，相比此前的最优模型，AlphaGenome 2…","published":"2026-11-11T15:19:51Z","seen":"2026-11-11T19:27:47Z","lang":"zh","country":"CN","source":{"id":"kite-ithome-com-f1cdd0","name":"ithome.com","domain":"ithome.com","outlet":{"wikidata":"Q28413779","name":"IThome","type":"website","country":"CN","designations":["website"]}},"via":"kite-ithome-com-f1cdd0","story":"st_kberqnck4z4u6dwhwvvq","category":"science-technology","category_p":0.9100000262260437,"sentiment":"positive","tone":0.23999999463558197,"political":0.009999999776482582},{"id":"n_kberqnck4z4u6dwhwvvq","seq":9899519,"kind":"article","title":"Google DeepMind launches AlphaGenome 2, trained on 100M+ cell profiles across 68 tissues to predict genetic mutation effects, for non-commercial research (Robert Hart/The Verge)","url":"https://www.techmeme.com/261111/p32","summary":"Robert Hart / The Verge : Google DeepMind launches AlphaGenome 2, trained on 100M+ cell profiles across 68 tissues to predict genetic mutation effects, for non-commercial research — DeepMind's new DNA model better predicts how mutations affect different cells, potentially opening paths to treatment.","published":"2026-11-11T15:10:04Z","seen":"2026-11-11T15:12:10Z","lang":"en","source":{"id":"techmeme","name":"Techmeme","domain":"techmeme.com","outlet":{"wikidata":"Q3390448","name":"Techmeme","type":"website","designations":["news aggregation website","website"]}},"via":"techmeme","topics":["technology"],"story":"st_kberqnck4z4u6dwhwvvq","category":"science-technology","category_p":0.949999988079071,"sentiment":"neutral","tone":0.23000000417232513,"political":0.019999999552965164},{"id":"n_kgac6jpamtaw26pl5ngq","seq":9973445,"kind":"article","title":"Google presenta AlphaGenome 2, un modelo que predice el impacto del ADN en 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DeepMind have unveiled a new AI model designed to unravel how changes in our DNA affect different cells, giving scientists a more detailed view of a notoriously difficult problem that could hold important clues to the causes of disease - and point the way to new treatments. AlphaGenome 2 is the successor […]","published":"2026-11-11T15:00:00Z","seen":"2026-11-11T19:32:57Z","lang":"en","country":"US","source":{"id":"kite-theverge-com-e8d31c","name":"theverge.com","domain":"theverge.com","outlet":{"wikidata":"Q2155442","name":"The Verge","type":"website","country":"US","designations":["news website","video game news website"]}},"via":"kite-theverge-com-e8d31c","topics":["smart-home","ai","google","health","science","tech"],"authors":["Robert Hart"],"story":"st_kberqnck4z4u6dwhwvvq","category":"science-technology","category_p":0.800000011920929,"sentiment":"neutral","tone":0.11999999731779099,"political":0.019999999552965164},{"id":"n_6jgcmihxgduljeiehgpa","seq":9953852,"kind":"article","title":"AlphaGenome 2, noul model AI de la DeepMind","url":"https://www.sfin.ro/alphagenome-2","published":"2026-11-11T13:33:00Z","seen":"2026-11-11T17:31:55Z","lang":"ro","country":"RO","source":{"id":"sfin.ro","name":"sfin.ro","domain":"sfin.ro"},"via":"gdelt-gkg-translingual","topics":["economy","science","health"],"story":"st_kberqnck4z4u6dwhwvvq","category":"science-technology","category_p":0.8999999761581421,"sentiment":"neutral","tone":-0.18000000715255737,"political":0.019999999552965164}]}